First published: 11 December 2019
While dehydrogenases play well-known roles in tricarboxylic acid (TCA) cycle of cell metabolism, which might maybe be widely explored for biomedical and chemical engineering makes use of, it is a immense project to beat the shortcomings (low stability and excessive costs) of recombinant dehydrogenases. Herein, we made an entertaining discovering that two‐dimension (2D) SnSe is able to mimicking native dehydrogenases to effectively catalyze hydrogen switch from 1‐(R)‐2‐(R’)‐ethanol teams. In opposite to susceptible native dehydrogenases, lactic dehydrogenase (LDH) for occasion, SnSe is highly tolerant to reaction situation adjustments ( e.g. pH, temperature and organic solvents) and displays extraordinary reusable functionality. Structure‐voice evaluation means that the one‐atom construction, Sn vacancy and hydrogen binding affinity of SnSe might maybe be accountable for his or her catalytic voice. Total, our findings clarify the principle file of a 2D SnSe nanozyme to mimic key dehydrogenases in cell metabolism.
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